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Image Search Results
Journal: Radiation Oncology (London, England)
Article Title: Oncogene addiction and radiation oncology: effect of radiotherapy with photons and carbon ions in ALK-EML4 translocated NSCLC
doi: 10.1186/s13014-017-0947-0
Figure Lengend Snippet: Selective antiproliferative effect of TAE684 in ALK-positive NSCLC. The kinase inhibition profile by TAE684 (IC 50 , mapped by TREE spot ) as well as its 2D and 3D molecular structures (adapted from PubChem) are shown ( a ). Cell proliferation was assessed by counting viable cells 72 post treatment with a cell-permeant DNA-binding fluorescent dye (CyQuant-Direct) ( b ). Alternatively, cell proliferation was monitored longitudinally by live microscopy and the confluence levels as well as representative photomicrographs are presented ( c and d ). TAE684 potently inhibited cell proliferation in ALK-positive H3122 NSCLC but was less or not effective in A549 and LLC cells, respectively. Bars represent mean ± SD. TK: tyrosine kinase; Ctrl: control
Article Snippet: The kinase inhibition spectrum (IC 50 ) of TAE684 was visualized (Fig. ) and mapped by
Techniques: Inhibition, Binding Assay, CyQUANT Assay, Microscopy, Control
Journal: ACS Medicinal Chemistry Letters
Article Title: Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors
doi: 10.1021/acsmedchemlett.7b00127
Figure Lengend Snippet: Kinase specificity of SBP3. Kinase screen measuring the binding of SBP3 (at 2 μM) to 55 kinases of the CMGC branch. The circles indicate “percent of control” values (see Supporting Experimental Procedures), with red circles indicating high SBP3 binding (the circle size is proportional to binding strength) and green circles indicating low or no binding (scores >35%). The values for kinases that strongly interact with SBP3 (scores ≤35%) are listed. Values for all kinases tested are summarized in Table S2. The image was generated using the TREEspot compound profile visualization tool (KINOMEscan, DiscoverX).
Article Snippet: The image was generated using the
Techniques: Binding Assay, Control, Generated